This week’s newsletter covers promising findings on THC/CBD for dementia care, questions about CBD product labeling accuracy, drug interactions to be aware of during chemotherapy, and a wide-ranging psychedelics research round-up touching on personality change, brain imaging, addiction therapy, and the ethics of 5-MeO-DMT.
Noteworthy Read
THC/CBD Oil Reduces Agitation in Dementia Patients (Neuroscience News)
A clinical study found that purified THC/CBD oil reduced agitation in dementia patients, a difficult symptom that can be distressing for patients and caregivers alike. The findings add to interest in cannabinoid-based approaches for neuropsychiatric symptoms in dementia, especially where conventional medications come with detrimental side-effects.
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More Noteworthy Reading
CBDA-Rich Cannabis Extract More Strongly Inhibits Epilepsy-Linked Sodium Channels Than Purified CBDA (Marijuana Herald)
New research found that a CBDA-rich cannabis extract more strongly inhibited sodium channels linked to epilepsy than purified CBDA alone. The study adds to the case for investigating whole-extract cannabinoid preparations, where minor compounds may influence biological activity in ways isolated molecules do not.
Many Hemp-Derived CBD Products Lack Accurate Labeling (NORML)
A new analysis found that many hemp-derived CBD products do not accurately match their label claims, reinforcing concerns about quality control in the unregulated CBD marketplace. The findings point to the need for stronger testing, clearer standards, and more accountability for products sold as wellness or therapeutic aids.
CBD Oil During Chemotherapy? (Dr. Andrew Weil)
Dr. Andrew Weil addresses the growing interest in CBD use during chemotherapy, including its potential role in easing treatment-related symptoms and supporting quality of life. The piece also highlights an important clinical reality: patients using CBD alongside cancer treatment should discuss it with their care team because cannabinoids can interact with medications processed by the liver.
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Research Round-Up
Psychedelics Linked to Lasting Increases in Openness and Drops in Neuroticism (Journal of Psychopharmacology)
A new study links psychedelic experiences with lasting personality changes, including increased openness and reduced neuroticism. The findings help explain why some psychedelic users report durable shifts in outlook, emotional flexibility, and self-perception long after the acute experience ends.
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Brain Imaging Analysis Reveals How Psychedelics Rewire Neural Circuits (PsyPost)
An international brain imaging analysis sheds light on how psychedelics alter communication across neural circuits involved in perception, emotion, and self-processing. The work helps connect the subjective effects of psychedelics with measurable changes in brain network activity.
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Integrating Psychedelic-Assisted Psychotherapy Into Addiction Care in the Czech Republic (Journal of Psychedelic Studies)
This paper examines how psychedelic-assisted psychotherapy could be integrated into addiction care in the Czech Republic. The discussion connects psychedelic therapy with real-world treatment systems, including clinical training, regulatory pathways, patient access, and the practical work of bringing emerging therapies into addiction medicine.
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Fabricated Ancestrality: The Sonoran Desert Toad, Psychedelic Globalization, and the Ecological Politics of 5-MeO-DMT (ScienceDirect)
This paper examines how global demand for 5-MeO-DMT has shaped narratives around the Sonoran desert toad, including claims of tradition, authenticity, and ancestral use. It further discusses how commercialization can reshape both species conservation and the stories used to legitimize psychoactive substances.
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The post Project CBD Newsletter: Cannabis for Alzheimer’s Agitation, CBD Labeling Concerns, and the Latest in Psychedelics Research appeared first on Project CBD.